ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CAPITAL COUNSEL LLC/NY's Holding History (CIK: 0001114928)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 13,000 Value ($000) $525 Avg Close — Range —
Q2 2015
Shares 13,000 Value ($000) $748 Avg Close — Range —
Q1 2015
Shares 13,000 Value ($000) $828 Avg Close — Range —
Q4 2014
Shares 13,000 Value ($000) $803 Avg Close — Range —
Q3 2014
Shares 13,000 Value ($000) $505 Avg Close — Range —
Q2 2014
Shares 12,000 Value ($000) $413 Avg Close — Range —