ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

FIRST TRUST ADVISORS LP's Holding History (CIK: 0001125816)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 2,252,501 Value ($000) $91,046 Avg Close — Range —
Q2 2015
Shares 1,779,289 Value ($000) $102,398 Avg Close — Range —
Q1 2015
Shares 1,385,594 Value ($000) $88,221 Avg Close — Range —
Q4 2014
Shares 1,559,143 Value ($000) $96,261 Avg Close — Range —