ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

PROFUND ADVISORS LLC's Holding History (CIK: 0001129919)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 84,961 Value ($000) $3,434 Avg Close — Range —
Q2 2015
Shares 89,443 Value ($000) $5,147 Avg Close — Range —
Q1 2015
Shares 93,309 Value ($000) $5,941 Avg Close — Range —
Q4 2014
Shares 87,394 Value ($000) $5,396 Avg Close — Range —
Q3 2014
Shares 78,528 Value ($000) $3,049 Avg Close — Range —
Q2 2014
Shares 77,723 Value ($000) $2,678 Avg Close — Range —
Q1 2014
Shares 95,593 Value ($000) $4,131 Avg Close — Range —
Q4 2013
Shares 75,738 Value ($000) $3,017 Avg Close — Range —
Q3 2013
Shares 60,360 Value ($000) $2,266 Avg Close — Range —
Q2 2013
Shares 56,437 Value ($000) $1,516 Avg Close — Range —