ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO's Holding History (CIK: 0001141802)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 382 Value ($000) $15 Avg Close — Range —
Q2 2015
Shares 382 Value ($000) $22 Avg Close — Range —
Q1 2015
Shares 144 Value ($000) $9 Avg Close — Range —
Q4 2014
Shares 46 Value ($000) $3 Avg Close — Range —
Q4 2013
Shares 50 Value ($000) $2 Avg Close — Range —