ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

ALTRINSIC GLOBAL ADVISORS LLC's Holding History (CIK: 0001167388)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 207,757 Value ($000) $8,398 Avg Close — Range —
Q2 2015
Shares 122,757 Value ($000) $7,065 Avg Close — Range —
Q1 2015
Shares 122,757 Value ($000) $7,816 Avg Close — Range —
Q4 2014
Shares 544,583 Value ($000) $33,622 Avg Close — Range —
Q3 2014
Shares 1,261,795 Value ($000) $48,995 Avg Close — Range —
Q2 2014
Shares 322,757 Value ($000) $11,119 Avg Close — Range —
Q1 2014
Shares 172,757 Value ($000) $7,465 Avg Close — Range —
Q4 2013
Shares 142,757 Value ($000) $5,687 Avg Close — Range —
Q3 2013
Shares 100,000 Value ($000) $3,754 Avg Close — Range —