ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CREDIT AGRICOLE S A's Holding History (CIK: 0001191672)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 16,245 Value ($000) $656 Avg Close — Range —
Q2 2015
Shares 16,245 Value ($000) $935 Avg Close — Range —
Q1 2015
Shares 15,145 Value ($000) $965 Avg Close — Range —
Q4 2014
Shares 2,600 Value ($000) $178 Avg Close — Range —
Q2 2014
Shares 570 Value ($000) $20 Avg Close — Range —
Q1 2014
Shares 430 Value ($000) $19 Avg Close — Range —
Q4 2013
Shares 2,126 Value ($000) $85 Avg Close — Range —
Q3 2013
Shares 2,002 Value ($000) $75 Avg Close — Range —
Q2 2013
Shares 2,078 Value ($000) $0 Avg Close — Range —