ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GEODE CAPITAL MANAGEMENT, LLC's Holding History (CIK: 0001214717)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 725,380 Value ($000) $29,301 Avg Close — Range —
Q2 2015
Shares 709,093 Value ($000) $40,784 Avg Close — Range —
Q1 2015
Shares 768,047 Value ($000) $48,877 Avg Close — Range —
Q4 2014
Shares 708,172 Value ($000) $43,722 Avg Close — Range —
Q3 2014
Shares 702,311 Value ($000) $27,270 Avg Close — Range —
Q2 2014
Shares 681,834 Value ($000) $23,489 Avg Close — Range —
Q1 2014
Shares 683,586 Value ($000) $29,537 Avg Close — Range —
Q4 2013
Shares 654,043 Value ($000) $26,057 Avg Close — Range —
Q3 2013
Shares 543,007 Value ($000) $20,384 Avg Close — Range —
Q2 2013
Shares 487,622 Value ($000) $13,102 Avg Close — Range —