ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

BRITISH COLUMBIA INVESTMENT MANAGEMENT Corp's Holding History (CIK: 0001228242)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 28,325 Value ($000) $1,145 Avg Close — Range —
Q2 2015
Shares 36,645 Value ($000) $2,109 Avg Close — Range —
Q1 2015
Shares 13,310 Value ($000) $847 Avg Close — Range —