ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GRAYBILL WEALTH MANAGEMENT, LTD.'s Holding History (CIK: 0001252007)

Note: Option positions (PUT/CALL) are excluded.

Q4 2014
Shares 61,225 Value ($000) $3,780 Avg Close — Range —
Q3 2014
Shares 90,240 Value ($000) $3,504 Avg Close — Range —
Q2 2014
Shares 90,920 Value ($000) $3,132 Avg Close — Range —