ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 57,140 Value ($000) $2,310 Avg Close — Range —
Q2 2015
Shares 57,140 Value ($000) $3,288 Avg Close — Range —
Q1 2015
Shares 57,140 Value ($000) $3,638 Avg Close — Range —
Q4 2014
Shares 96,303 Value ($000) $5,946 Avg Close — Range —
Q3 2014
Shares 96,303 Value ($000) $3,739 Avg Close — Range —
Q2 2014
Shares 96,303 Value ($000) $3,318 Avg Close — Range —
Q1 2014
Shares 96,303 Value ($000) $4,161 Avg Close — Range —
Q4 2013
Shares 247,036 Value ($000) $9,842 Avg Close — Range —
Q3 2013
Shares 247,036 Value ($000) $9,274 Avg Close — Range —
Q2 2013
Shares 247,036 Value ($000) $6,638 Avg Close — Range —