ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

MILLENNIUM MANAGEMENT LLC's Holding History (CIK: 0001273087)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 180,814 Value ($000) $7,309 Avg Close — Range —
Q2 2015
Shares 368,056 Value ($000) $21,182 Avg Close — Range —
Q1 2015
Shares 6,800 Value ($000) $433 Avg Close — Range —
Q2 2014
Shares 198,138 Value ($000) $6,826 Avg Close — Range —
Q1 2014
Shares 208,381 Value ($000) $9,004 Avg Close — Range —
Q4 2013
Shares 40,000 Value ($000) $1,594 Avg Close — Range —
Q3 2013
Shares 260,133 Value ($000) $9,765 Avg Close — Range —
Q2 2013
Shares 814,318 Value ($000) $21,881 Avg Close — Range —