ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

JANUS HENDERSON GROUP PLC's Holding History (CIK: 0001274173)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 12,763 Value ($000) $516 Avg Close — Range —
Q2 2015
Shares 12,763 Value ($000) $734 Avg Close — Range —
Q1 2015
Shares 12,763 Value ($000) $812 Avg Close — Range —