ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

SECTORAL ASSET MANAGEMENT INC's Holding History (CIK: 0001274413)

Note: Option positions (PUT/CALL) are excluded.

Q1 2014
Shares 882,101 Value ($000) $38,116 Avg Close — Range —
Q4 2013
Shares 1,222,401 Value ($000) $48,700 Avg Close — Range —
Q3 2013
Shares 441,401 Value ($000) $16,570 Avg Close — Range —