ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GUGGENHEIM CAPITAL LLC's Holding History (CIK: 0001283072)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 232,583 Value ($000) $9,401 Avg Close — Range —
Q2 2015
Shares 252,737 Value ($000) $14,545 Avg Close — Range —
Q1 2015
Shares 203,375 Value ($000) $12,949 Avg Close — Range —
Q4 2014
Shares 187,639 Value ($000) $11,585 Avg Close — Range —
Q3 2014
Shares 172,572 Value ($000) $6,700 Avg Close — Range —
Q2 2014
Shares 184,339 Value ($000) $6,350 Avg Close — Range —
Q1 2014
Shares 196,605 Value ($000) $8,496 Avg Close — Range —
Q4 2013
Shares 177,863 Value ($000) $7,086 Avg Close — Range —
Q3 2013
Shares 173,906 Value ($000) $6,528 Avg Close — Range —
Q2 2013
Shares 189,890 Value ($000) $5,102 Avg Close — Range —