ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CANADA PENSION PLAN INVESTMENT BOARD's Holding History (CIK: 0001283718)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 117,796 Value ($000) $4,761 Avg Close — Range —
Q2 2015
Shares 4,500 Value ($000) $259 Avg Close — Range —
Q1 2015
Shares 10,300 Value ($000) $656 Avg Close — Range —