ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Pine River Capital Management L.P.'s Holding History (CIK: 0001288136)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 12,400 Value ($000) $501 Avg Close — Range —
Q2 2015
Shares 8,700 Value ($000) $501 Avg Close — Range —
Q4 2014
Shares 17,866 Value ($000) $1,103 Avg Close — Range —
Q2 2014
Shares 14,872 Value ($000) $512 Avg Close — Range —