ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Broderick Brian C's Holding History (CIK: 0001314376)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 17,907 Value ($000) $723 Avg Close — Range —
Q2 2015
Shares 15,657 Value ($000) $902 Avg Close — Range —
Q1 2015
Shares 15,657 Value ($000) $997 Avg Close — Range —
Q4 2014
Shares 15,657 Value ($000) $967 Avg Close — Range —
Q3 2014
Shares 14,609 Value ($000) $567 Avg Close — Range —
Q2 2014
Shares 13,453 Value ($000) $464 Avg Close — Range —