ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 131,170 Value ($000) $5,302 Avg Close — Range —
Q2 2015
Shares 149,285 Value ($000) $8,591 Avg Close — Range —