ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CAPITAL FUND MANAGEMENT S.A.'s Holding History (CIK: 0001323645)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 558,743 Value ($000) $22,584 Avg Close — Range —
Q2 2015
Shares 466,541 Value ($000) $26,849 Avg Close — Range —
Q1 2015
Shares 8,402 Value ($000) $535 Avg Close — Range —
Q4 2014
Shares 17,154 Value ($000) $1,059 Avg Close — Range —
Q3 2014
Shares 87,430 Value ($000) $3,395 Avg Close — Range —
Q1 2014
Shares 50,466 Value ($000) $2,181 Avg Close — Range —
Q4 2013
Shares 118,657 Value ($000) $4,727 Avg Close — Range —
Q3 2013
Shares 38,172 Value ($000) $1,433 Avg Close — Range —
Q2 2013
Shares 160,534 Value ($000) $4,314 Avg Close — Range —