ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

BROWN ADVISORY INC's Holding History (CIK: 0001345929)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 5,847 Value ($000) $237 Avg Close — Range —
Q1 2015
Shares 5,665 Value ($000) $361 Avg Close — Range —
Q4 2014
Shares 5,585 Value ($000) $345 Avg Close — Range —