ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Clearbridge Investments, LLC's Holding History (CIK: 0001348883)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 9,385,080 Value ($000) $379,345 Avg Close — Range —
Q2 2015
Shares 9,423,002 Value ($000) $542,294 Avg Close — Range —
Q1 2015
Shares 9,586,157 Value ($000) $610,351 Avg Close — Range —
Q4 2014
Shares 9,034,520 Value ($000) $557,791 Avg Close — Range —
Q3 2014
Shares 8,988,756 Value ($000) $349,033 Avg Close — Range —
Q2 2014
Shares 8,239,358 Value ($000) $283,846 Avg Close — Range —
Q1 2014
Shares 7,344,262 Value ($000) $317,346 Avg Close — Range —
Q4 2013
Shares 7,197,661 Value ($000) $286,755 Avg Close — Range —
Q3 2013
Shares 7,215,568 Value ($000) $270,872 Avg Close — Range —
Q2 2013
Shares 6,822,525 Value ($000) $183,322 Avg Close — Range —