ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

ProShare Advisors LLC's Holding History (CIK: 0001357955)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 95,887 Value ($000) $3,876 Avg Close — Range —
Q2 2015
Shares 102,178 Value ($000) $5,880 Avg Close — Range —
Q1 2015
Shares 124,035 Value ($000) $7,897 Avg Close — Range —
Q4 2014
Shares 109,540 Value ($000) $6,763 Avg Close — Range —
Q3 2014
Shares 111,129 Value ($000) $4,315 Avg Close — Range —
Q2 2014
Shares 133,215 Value ($000) $4,589 Avg Close — Range —
Q1 2014
Shares 206,761 Value ($000) $8,934 Avg Close — Range —
Q4 2013
Shares 62,994 Value ($000) $2,510 Avg Close — Range —
Q3 2013
Shares 114,465 Value ($000) $4,297 Avg Close — Range —
Q2 2013
Shares 96,902 Value ($000) $2,604 Avg Close — Range —