ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Aperio Group, LLC's Holding History (CIK: 0001364615)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 8,154 Value ($000) $330 Avg Close — Range —
Q2 2015
Shares 4,365 Value ($000) $251 Avg Close — Range —
Q1 2015
Shares 3,751 Value ($000) $239 Avg Close — Range —