ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Zurcher Kantonalbank (Zurich Cantonalbank)'s Holding History (CIK: 0001368163)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 8,742 Value ($000) $353 Avg Close — Range —
Q2 2015
Shares 8,835 Value ($000) $508 Avg Close — Range —
Q1 2015
Shares 8,742 Value ($000) $557 Avg Close — Range —
Q3 2014
Shares 1,100 Value ($000) $43 Avg Close — Range —
Q2 2014
Shares 141,100 Value ($000) $4,861 Avg Close — Range —
Q1 2014
Shares 78,000 Value ($000) $3,371 Avg Close — Range —
Q4 2013
Shares 95,000 Value ($000) $3,785 Avg Close — Range —
Q3 2013
Shares 75,000 Value ($000) $2,816 Avg Close — Range —
Q2 2013
Shares 30,000 Value ($000) $806 Avg Close — Range —
Q1 2013
Shares 30,000 Value ($000) $508 Avg Close — Range —
Q4 2012
Shares 145,000 Value ($000) $1,517 Avg Close — Range —
Q3 2012
Shares 37,000 Value ($000) $521 Avg Close — Range —
Q2 2012
Shares 40,000 Value ($000) $480 Avg Close — Range —
Q1 2012
Shares 95,000 Value ($000) $833 Avg Close — Range —
Q4 2011
Shares 43,000 Value ($000) $310 Avg Close — Range —