ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

MYCIO WEALTH PARTNERS, LLC's Holding History (CIK: 0001371726)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 2,008 Value ($000) $81 Avg Close — Range —
Q2 2015
Shares 2,000 Value ($000) $115 Avg Close — Range —
Q1 2015
Shares 2,000 Value ($000) $127 Avg Close — Range —
Q4 2014
Shares 500 Value ($000) $31 Avg Close — Range —