ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

NORGES BANK's Holding History (CIK: 0001374170)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 1,019,236 Value ($000) $41,197 Avg Close — Range —
Q2 2015
Shares 1,059,580 Value ($000) $60,979 Avg Close — Range —
Q1 2015
Shares 955,196 Value ($000) $60,818 Avg Close — Range —
Q4 2014
Shares 880,326 Value ($000) $54,351 Avg Close — Range —
Q3 2014
Shares 752,077 Value ($000) $29,203 Avg Close — Range —
Q2 2014
Shares 752,077 Value ($000) $25,909 Avg Close — Range —
Q1 2014
Shares 752,077 Value ($000) $32,497 Avg Close — Range —
Q4 2013
Shares 752,077 Value ($000) $29,962 Avg Close — Range —
Q3 2013
Shares 726,482 Value ($000) $27,273 Avg Close — Range —
Q2 2013
Shares 483,296 Value ($000) $12,987 Avg Close — Range —
Q1 2013
Shares 562,014 Value ($000) $9,520 Avg Close — Range —
Q3 2012
Shares 383,610 Value ($000) $5,397 Avg Close — Range —
Q2 2012
Shares 383,610 Value ($000) $4,649 Avg Close — Range —