ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

PRELUDE CAPITAL MANAGEMENT, LLC's Holding History (CIK: 0001387508)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 7,231 Value ($000) $292 Avg Close — Range —
Q2 2015
Shares 7,110 Value ($000) $409 Avg Close — Range —
Q1 2015
Shares 7,610 Value ($000) $485 Avg Close — Range —
Q4 2014
Shares 7,584 Value ($000) $468 Avg Close — Range —
Q1 2014
Shares 2,020 Value ($000) $87 Avg Close — Range —
Q4 2013
Shares 8,202 Value ($000) $327 Avg Close — Range —
Q3 2013
Shares 7,126 Value ($000) $268 Avg Close — Range —
Q2 2013
Shares 15,000 Value ($000) $403 Avg Close — Range —
Q1 2013
Shares 20,000 Value ($000) $339 Avg Close — Range —