ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Bank of New York Mellon Corp's Holding History (CIK: 0001390777)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 558,607 Value ($000) $22,579 Avg Close — Range —
Q2 2015
Shares 560,228 Value ($000) $32,242 Avg Close — Range —
Q1 2015
Shares 770,229 Value ($000) $49,040 Avg Close — Range —
Q4 2014
Shares 714,450 Value ($000) $44,110 Avg Close — Range —
Q3 2014
Shares 726,675 Value ($000) $28,217 Avg Close — Range —
Q2 2014
Shares 729,333 Value ($000) $25,125 Avg Close — Range —
Q1 2014
Shares 673,705 Value ($000) $29,111 Avg Close — Range —
Q4 2013
Shares 652,662 Value ($000) $26,002 Avg Close — Range —
Q3 2013
Shares 653,165 Value ($000) $24,519 Avg Close — Range —
Q2 2013
Shares 654,705 Value ($000) $17,591 Avg Close — Range —