ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Employees Retirement System of Texas's Holding History (CIK: 0001398739)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 28,000 Value ($000) $1,132 Avg Close — Range —
Q2 2015
Shares 41,000 Value ($000) $2,360 Avg Close — Range —
Q1 2015
Shares 46,000 Value ($000) $2,929 Avg Close — Range —
Q4 2014
Shares 77,000 Value ($000) $4,754 Avg Close — Range —
Q3 2014
Shares 143,000 Value ($000) $5,553 Avg Close — Range —
Q2 2014
Shares 143,000 Value ($000) $4,926 Avg Close — Range —
Q1 2014
Shares 49,000 Value ($000) $2,117 Avg Close — Range —
Q4 2013
Shares 28,000 Value ($000) $1,116 Avg Close — Range —