ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

LPL Financial LLC's Holding History (CIK: 0001403438)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 13,187 Value ($000) $547 Avg Close — Range —
Q2 2015
Shares 25,733 Value ($000) $1,427 Avg Close — Range —
Q1 2015
Shares 25,040 Value ($000) $1,582 Avg Close — Range —
Q4 2014
Shares 22,205 Value ($000) $1,371 Avg Close — Range —
Q3 2014
Shares 21,444 Value ($000) $812 Avg Close — Range —
Q2 2014
Shares 14,715 Value ($000) $507 Avg Close — Range —
Q1 2014
Shares 12,559 Value ($000) $543 Avg Close — Range —
Q4 2013
Shares 8,659 Value ($000) $345 Avg Close — Range —