ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Robeco Institutional Asset Management B.V.'s Holding History (CIK: 0001418773)

Note: Option positions (PUT/CALL) are excluded.

Q1 2014
Shares 828 Value ($000) $36 Avg Close — Range —
Q4 2013
Shares 828 Value ($000) $33 Avg Close — Range —
Q3 2013
Shares 1,160 Value ($000) $44 Avg Close — Range —
Q2 2013
Shares 1,160 Value ($000) $31 Avg Close — Range —