ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CITADEL ADVISORS LLC's Holding History (CIK: 0001423053)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 312,428 Value ($000) $17,981 Avg Close — Range —
Q1 2015
Shares 92,850 Value ($000) $5,912 Avg Close — Range —
Q4 2014
Shares 81,191 Value ($000) $5,013 Avg Close — Range —
Q3 2014
Shares 144,269 Value ($000) $5,602 Avg Close — Range —
Q2 2014
Shares 62,192 Value ($000) $2,143 Avg Close — Range —
Q1 2014
Shares 11,431 Value ($000) $494 Avg Close — Range —
Q4 2013
Shares 95,233 Value ($000) $3,794 Avg Close — Range —
Q2 2013
Shares 7,515 Value ($000) $202 Avg Close — Range —