ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

GAM Holding AG's Holding History (CIK: 0001438848)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 2,580 Value ($000) $104 Avg Close — Range —
Q2 2015
Shares 2,580 Value ($000) $148 Avg Close — Range —
Q1 2015
Shares 1,800 Value ($000) $115 Avg Close — Range —