ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Korea Investment CORP's Holding History (CIK: 0001441689)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015

Shares 25,100 Value ($000) $1,014 Avg Close — Range —

Q2 2015

Shares 59,300 Value ($000) $3,413 Avg Close — Range —

Q1 2015

Shares 31,300 Value ($000) $1,993 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2015	25,100	$1,014	—	—
Q2 2015	59,300	$3,413	—	—
Q1 2015	31,300	$1,993	—	—