ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

SUSQUEHANNA INTERNATIONAL GROUP, LLP's Holding History (CIK: 0001446194)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 584,669 Value ($000) $23,632 Avg Close — Range —
Q2 2015
Shares 633,812 Value ($000) $36,476 Avg Close — Range —
Q1 2015
Shares 453,993 Value ($000) $28,906 Avg Close — Range —
Q4 2014
Shares 488,254 Value ($000) $30,145 Avg Close — Range —
Q3 2014
Shares 719,313 Value ($000) $27,931 Avg Close — Range —
Q2 2014
Shares 786,460 Value ($000) $27,094 Avg Close — Range —
Q1 2014
Shares 372,029 Value ($000) $16,076 Avg Close — Range —
Q4 2013
Shares 56,726 Value ($000) $2,260 Avg Close — Range —
Q3 2013
Shares 252,865 Value ($000) $9,493 Avg Close — Range —
Q2 2013
Shares 302,504 Value ($000) $8,129 Avg Close — Range —