ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

LS Investment Advisors, LLC's Holding History (CIK: 0001455845)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 1,842 Value ($000) $74 Avg Close — Range —
Q2 2015
Shares 1,842 Value ($000) $106 Avg Close — Range —
Q1 2015
Shares 1,842 Value ($000) $117 Avg Close — Range —