ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Reynders McVeigh Capital Management, LLC's Holding History (CIK: 0001455969)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 111,313 Value ($000) $4,499 Avg Close — Range —
Q2 2015
Shares 110,388 Value ($000) $6,353 Avg Close — Range —
Q1 2015
Shares 111,718 Value ($000) $7,113 Avg Close — Range —
Q4 2014
Shares 110,483 Value ($000) $6,821 Avg Close — Range —
Q3 2014
Shares 107,858 Value ($000) $4,188 Avg Close — Range —
Q2 2014
Shares 70,283 Value ($000) $2,421 Avg Close — Range —
Q1 2014
Shares 21,080 Value ($000) $911 Avg Close — Range —
Q4 2013
Shares 8,165 Value ($000) $325 Avg Close — Range —