ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

DekaBank Deutsche Girozentrale's Holding History (CIK: 0001456228)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 74,700 Value ($000) $3,019 Avg Close — Range —
Q2 2015
Shares 69,800 Value ($000) $4,017 Avg Close — Range —
Q1 2015
Shares 68,700 Value ($000) $4,374 Avg Close — Range —
Q4 2014
Shares 98,100 Value ($000) $6,056 Avg Close — Range —
Q3 2014
Shares 116,900 Value ($000) $4,539 Avg Close — Range —
Q2 2014
Shares 67,400 Value ($000) $2,322 Avg Close — Range —
Q1 2014
Shares 69,900 Value ($000) $3,020 Avg Close — Range —
Q4 2013
Shares 65,700 Value ($000) $2,624 Avg Close — Range —
Q3 2013
Shares 63,100 Value ($000) $2,369 Avg Close — Range —