ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Artisan Partners Limited Partnership's Holding History (CIK: 0001466153)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 75,049 Value ($000) $3,033 Avg Close — Range —
Q2 2015
Shares 73,051 Value ($000) $4,204 Avg Close — Range —
Q1 2015
Shares 209,242 Value ($000) $13,322 Avg Close — Range —
Q4 2014
Shares 3,852,643 Value ($000) $237,862 Avg Close — Range —
Q3 2014
Shares 7,368,499 Value ($000) $286,119 Avg Close — Range —
Q2 2014
Shares 7,571,076 Value ($000) $260,824 Avg Close — Range —
Q1 2014
Shares 8,761,769 Value ($000) $378,596 Avg Close — Range —
Q4 2013
Shares 10,776,147 Value ($000) $429,322 Avg Close — Range —
Q3 2013
Shares 10,633,737 Value ($000) $399,190 Avg Close — Range —
Q2 2013
Shares 9,164,743 Value ($000) $246,256,645 Avg Close — Range —