ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Sumitomo Mitsui Trust Holdings, Inc.'s Holding History (CIK: 0001475365)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 315,165 Value ($000) $12,739 Avg Close — Range —
Q2 2015
Shares 315,420 Value ($000) $18,152 Avg Close — Range —
Q1 2015
Shares 296,527 Value ($000) $18,880 Avg Close — Range —