ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 395,505 Value ($000) $16,467 Avg Close — Range —
Q2 2015
Shares 43,805 Value ($000) $2,521 Avg Close — Range —
Q1 2015
Shares 23,411 Value ($000) $1,491 Avg Close — Range —
Q4 2013
Shares 15,811 Value ($000) $630 Avg Close — Range —
Q3 2013
Shares 17,411 Value ($000) $653 Avg Close — Range —
Q2 2013
Shares 10,790 Value ($000) $290 Avg Close — Range —