ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Daiwa Securities Group Inc.'s Holding History (CIK: 0001481045)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 2,800 Value ($000) $113 Avg Close — Range —
Q2 2015
Shares 2,600 Value ($000) $150 Avg Close — Range —
Q1 2015
Shares 2,300 Value ($000) $146 Avg Close — Range —