ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

SIMPLEX TRADING, LLC's Holding History (CIK: 0001488542)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 5,477 Value ($000) $221 Avg Close — Range —
Q2 2015
Shares 50,499 Value ($000) $2,906 Avg Close — Range —
Q1 2015
Shares 40,248 Value ($000) $2,562 Avg Close — Range —