ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Hemenway Trust Co LLC's Holding History (CIK: 0001494234)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 36,485 Value ($000) $1,475 Avg Close — Range —
Q2 2015
Shares 35,185 Value ($000) $2,025 Avg Close — Range —
Q1 2015
Shares 34,685 Value ($000) $2,208 Avg Close — Range —
Q4 2014
Shares 35,135 Value ($000) $2,169 Avg Close — Range —
Q3 2014
Shares 34,885 Value ($000) $1,355 Avg Close — Range —
Q2 2014
Shares 26,145 Value ($000) $901 Avg Close — Range —