ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

TOBAM's Holding History (CIK: 0001527488)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 65,035 Value ($000) $2,629 Avg Close — Range —
Q2 2015
Shares 110,772 Value ($000) $6,375 Avg Close — Range —
Q1 2015
Shares 91,845 Value ($000) $5,848 Avg Close — Range —