ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Tower Research Capital LLC (TRC)'s Holding History (CIK: 0001533421)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 9,265 Value ($000) $533 Avg Close — Range —
Q1 2015
Shares 1,697 Value ($000) $108 Avg Close — Range —
Q4 2014
Shares 1,263 Value ($000) $78 Avg Close — Range —
Q3 2014
Shares 3,138 Value ($000) $122 Avg Close — Range —
Q2 2014
Shares 15 Value ($000) $1 Avg Close — Range —
Q1 2014
Shares 2,197 Value ($000) $95 Avg Close — Range —
Q4 2013
Shares 1,314 Value ($000) $52 Avg Close — Range —
Q3 2013
Shares 8,890 Value ($000) $334 Avg Close — Range —
Q2 2013
Shares 3,501 Value ($000) $94 Avg Close — Range —