ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

SABBY MANAGEMENT, LLC's Holding History (CIK: 0001535610)

Note: Option positions (PUT/CALL) are excluded.

Q4 2013
Shares 13,157 Value ($000) $524 Avg Close — Range —
Q3 2013
Shares 11,663 Value ($000) $438 Avg Close — Range —