ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

FineMark National Bank & Trust's Holding History (CIK: 0001537720)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 714 Value ($000) $29 Avg Close — Range —
Q2 2015
Shares 714 Value ($000) $41 Avg Close — Range —
Q1 2015
Shares 1,229 Value ($000) $78 Avg Close — Range —
Q4 2014
Shares 714 Value ($000) $44 Avg Close — Range —
Q3 2014
Shares 738 Value ($000) $29 Avg Close — Range —
Q2 2014
Shares 738 Value ($000) $25 Avg Close — Range —
Q1 2014
Shares 805 Value ($000) $35 Avg Close — Range —
Q2 2013
Shares 170 Value ($000) $5 Avg Close — Range —