ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Swiss National Bank's Holding History (CIK: 0001582202)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 213,600 Value ($000) $8,634 Avg Close — Range —
Q2 2015
Shares 192,000 Value ($000) $11,050 Avg Close — Range —
Q1 2015
Shares 180,000 Value ($000) $11,461 Avg Close — Range —
Q4 2014
Shares 130,300 Value ($000) $8,045 Avg Close — Range —
Q3 2014
Shares 127,300 Value ($000) $4,943 Avg Close — Range —
Q2 2014
Shares 128,900 Value ($000) $4,441 Avg Close — Range —
Q1 2014
Shares 128,900 Value ($000) $5,570 Avg Close — Range —
Q4 2013
Shares 99,700 Value ($000) $3,972 Avg Close — Range —
Q3 2013
Shares 97,500 Value ($000) $3,660 Avg Close — Range —
Q2 2013
Shares 102,300 Value ($000) $2,749 Avg Close — Range —