ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

Blume Capital Management, Inc.'s Holding History (CIK: 0001587192)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 90 Value ($000) $4 Avg Close — Range —
Q2 2015
Shares 90 Value ($000) $5 Avg Close — Range —
Q1 2015
Shares 90 Value ($000) $6 Avg Close — Range —
Q4 2014
Shares 90 Value ($000) $6 Avg Close — Range —
Q3 2014
Shares 90 Value ($000) $3 Avg Close — Range —
Q2 2014
Shares 90 Value ($000) $3 Avg Close — Range —